behavior/neurological
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• increased head dips in an elevated zero maze and increased total distance travelled in the open arms of the elevated zero maze suggesting habituation
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• indicated by increased exploration of familiar arms in a Y-maze
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• impaired spatial memory indicated by longer time and further distance to find escape hole in the Barnes maze
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• at 3, 5, and 6 month of age using an inverted grid test
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• with increased speed and total distance traveled
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• reduced overall time of interaction, regardless of the other cage occupant
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• with a large range in age of onset, severity, and progression
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nervous system
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• with a large range in age of onset, severity, and progression
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• at 3, 5, and 6 month of age using an inverted grid test
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• increased volume
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• immature synaptic networks indicated by aberrant synchronicity and elevated spike counts in cultured neurons
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