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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arel1em1Bbc
endonuclease-mediated mutation 1, Bill B Chen
MGI:6392853
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arel1em1Bbc/Arel1em1Bbc C57BL/6J-Arel1em1Bbc MGI:6393249
ht2
 		Arel1em1Bbc/Arel1+ C57BL/6J-Arel1em1Bbc MGI:6393250


Genotype
MGI:6393249
hm1
Allelic
Composition		 Arel1em1Bbc/Arel1em1Bbc
Genetic
Background		 C57BL/6J-Arel1em1Bbc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arel1em1Bbc mutation (0 available); any Arel1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased acute inflammation ( J:280563 )
• decrease in pulmonary inflammatory injury markers (bronchoalveolar lavage fluid (BALF) protein concentration, cell count and proinflammatory cytokine release) after intra tracheal LPS challenge
decreased response to antigen ( J:280563 )
• decrease in pulmonary inflammatory injury markers (bronchoalveolar lavage fluid (BALF) protein concentration, cell count and proinflammatory cytokine release) after intra tracheal LPS challenge




Genotype
MGI:6393250
ht2
Allelic
Composition		 Arel1em1Bbc/Arel1+
Genetic
Background		 C57BL/6J-Arel1em1Bbc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arel1em1Bbc mutation (0 available); any Arel1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased acute inflammation ( J:280563 )
• decrease in pulmonary inflammatory injury markers (bronchoalveolar lavage fluid (BALF) protein concentration, cell count and proinflammatory cytokine release) after intra tracheal LPS challenge
decreased response to antigen ( J:280563 )
• decrease in pulmonary inflammatory injury markers (bronchoalveolar lavage fluid (BALF) protein concentration, cell count and proinflammatory cytokine release) after intra tracheal LPS challenge




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory