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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		9030622O22Rikem1Eem
endonuclease-mediated mutation 1, Edward E Morrisey
MGI:6392887
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		9030622O22Rikem1Eem/9030622O22Rikem1Eem involves: C57BL/6 * CD-1 MGI:6392888
cx2
 		9030622O22Rikem1Eem/9030622O22Rik+
Foxa2tm1.1Khk/Foxa2+ 		involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:6393316


Genotype
MGI:6392888
hm1
Allelic
Composition		 9030622O22Rikem1Eem/9030622O22Rikem1Eem
Genetic
Background		 involves: C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
9030622O22Rikem1Eem mutation (0 available); any 9030622O22Rik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
lung inflammation ( J:284174 )
• areas of peribronchial inflammation are seen by 1 year of age
abnormal respiratory mucosa goblet cell morphology ( J:284174 )
• goblet cell metaplasia is seen by 1 year of age, but not at 8-12 weeks of age

homeostasis/metabolism
increased susceptibility to injury ( J:284174 )
• mice show defects in regeneration of the airway epithelium after injury with naphthalene, including incomplete re-epithelialization of the lung airways, peribronchial and perivascular inflammation, goblet cell metaplasia

immune system
lung inflammation ( J:284174 )
• areas of peribronchial inflammation are seen by 1 year of age




Genotype
MGI:6393316
cx2
Allelic
Composition		 9030622O22Rikem1Eem/9030622O22Rik+
Foxa2tm1.1Khk/Foxa2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
9030622O22Rikem1Eem mutation (0 available); any 9030622O22Rik mutation (1 available)
Foxa2tm1.1Khk mutation (0 available); any Foxa2 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
respiratory system inflammation ( J:284174 )
• by 8-12 weeks of age, mice exhibit areas of peribronchial and perivascular inflammation, consisting predominantly of B220+ B cells
• inflammation is most notable in the subepithelial region of airway branch points
• CD3e+ T cells are found interspersed among the B cells at foci of inflammation

respiratory system
respiratory system inflammation ( J:284174 )
• by 8-12 weeks of age, mice exhibit areas of peribronchial and perivascular inflammation, consisting predominantly of B220+ B cells
• inflammation is most notable in the subepithelial region of airway branch points
• CD3e+ T cells are found interspersed among the B cells at foci of inflammation
abnormal respiratory mucosa goblet cell morphology ( J:284174 )
• goblet cell metaplasia, with greater numbers of goblet cells than in single Foxa2 heterozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory