Phenotypes associated with this allele

• Allele Symbol: Scn11a^em1Akoi
• Allele Name: endonuclease-mediated mutation 1, Akio Koizumi
• Allele ID: MGI:6392908
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Scn11a^em1Akoi/Scn11a^+	involves: C57BL/6	MGI:6392909

Genotype
MGI:6392909

ht1

• Allelic Composition: Scn11a^em1Akoi/Scn11a⁺
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal thermal nociception ( J:268684 )

• the number of nociceptive behaviors in the cold plate test is higher than in wild-type mice, indicating cold hypersensitivity

• however, mice exhibit normal locomotor activity at 8-9 weeks and 36-38 weeks of age

decreased thermal nociceptive threshold ( J:268684 )

• mice exhibit a shorter paw withdrawal latency in the Hargreaves test indicating thermal hypersensitivity

nervous system

abnormal nervous system electrophysiology ( J:268684 )

• dorsal root ganglion neurons from 8-9 week old mice show higher input impedance

abnormal action potential ( J:268684 )

• dorsal root ganglion neurons from 8-9 week old mice show increased firing frequency of evoked action potentials but no difference in resting membrane potential

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial episodic pain syndrome 3		DOID:0111731	OMIM:615552	J:268684