Phenotypes associated with this allele

• Allele Symbol: Yif1b^tm1.2Ics
• Allele Name: targeted mutation 1.2, Mouse Clinical Institute
• Allele ID: MGI:6393258
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Yif1b^tm1.2Ics/Yif1b^tm1.2Ics	involves: 129 * 129S2/SvPas * C57BL/6J	MGI:6400958

Genotype
MGI:6400958

hm1

• Allelic Composition: Yif1b^tm1.2Ics/Yif1b^tm1.2Ics
• Genetic Background: involves: 129 * 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal Golgi apparatus morphology ( J:284998 )

• disorganized Golgi architecture in hippocampal CA1 pyramidal neurons derived from E18 mice

• on brain sections, volume of Golgi apparatus in adult hippocampal CA1 pyramidal neurons is reduced to one third of that in wild-type neurons; an increased amount of fragmented Golgi ribbons composed of shorted stacks is observed

abnormal Golgi cisterna morphology ( J:284998 )

• number of Golgi cisternae is increased in hippocampal CA1 pyramidal neurons derived from adult mice

• more irregular and sometimes wider cisternae giving rise to dilated cisternae are observed, esp. at the lateral rims

• length and surface of cisternae composing the Golgi ribbons of CA1 pyramidal neurons is reduced

abnormal Golgi vesicle transport ( J:284998 )

• traffic of the Vesicular Stomatitis Virus G Protein (VSVts405-G-eGFP VSVG) protein marker is accelerated in primary cultures of hippocampal neurons derived from E18 mutant mice indicating accelerated anterograde transport