All Phenotypes Dhx15<tm1c(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dhx15^{tm1c(EUCOMM)Wtsi}
targeted mutation 1c, Wellcome Trust Sanger Institute
MGI:6393262

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dhx15^{tm1c(EUCOMM)Wtsi}/Dhx15^{tm1c(EUCOMM)Wtsi} Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * C3H * C57BL/6N	MGI:6393270
cn2	Dhx15^{tm1c(EUCOMM)Wtsi}/Dhx15^{tm1c(EUCOMM)Wtsi} Tg(Cd4-cre)1Cwi/0	involves: C3H * C57BL/6N * DBA/2	MGI:6393268

Allelic Composition	Dhx15^{tm1c(EUCOMM)Wtsi}/Dhx15^{tm1c(EUCOMM)Wtsi} Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * C3H * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Dhx15^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Dhx15 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell proliferation ( J:284624 )

• in a competitive fitness assay upon activation

abnormal B cell differentiation ( J:284624 )

decreased B cell number ( J:284624 )

• 4-fold reduction, not restricted to a particular B cell subtype

• 4-fold reduction of CD3+ splenic B cells

decreased pre-B cell number ( J:284624 )

• in the bone marrow

decreased spleen weight ( J:284624 )

spleen hypoplasia ( J:284624 )

cellular

decreased B cell proliferation ( J:284624 )

• in a competitive fitness assay upon activation

hematopoietic system

decreased B cell proliferation ( J:284624 )

• in a competitive fitness assay upon activation

abnormal B cell differentiation ( J:284624 )

decreased B cell number ( J:284624 )

• 4-fold reduction, not restricted to a particular B cell subtype

• 4-fold reduction of CD3+ splenic B cells

decreased pre-B cell number ( J:284624 )

• in the bone marrow

decreased spleen weight ( J:284624 )

spleen hypoplasia ( J:284624 )

Allelic Composition	Dhx15^{tm1c(EUCOMM)Wtsi}/Dhx15^{tm1c(EUCOMM)Wtsi} Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: C3H * C57BL/6N * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dhx15^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Dhx15 mutation (41 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:284624 )

decreased CD8-positive, alpha-beta T cell number ( J:284624 )

immune system

decreased CD4-positive, alpha-beta T cell number ( J:284624 )

decreased CD8-positive, alpha-beta T cell number ( J:284624 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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