Phenotypes associated with this allele

• Allele Symbol: Rab32^{tm1c(KOMP)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6393526
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Rab32^tm1c(KOMP)Wtsi/Rab32^tm1c(KOMP)Wtsi Tg(Itgax-cre)1-1Reiz/0	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * CBA	MGI:6393530

Genotype
MGI:6393530

cn1

• Allelic Composition: Rab32^{tm1c(KOMP)Wtsi}/Rab32^{tm1c(KOMP)Wtsi}; Tg(Itgax-cre)1-1Reiz/0
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

decreased colon length ( J:267497 )

• more severely shortened colon during dextran sodium sulfate (DSS)-induced colitis

increased susceptibility to induced colitis ( J:267497 )

• increased, and earlier onset of, weight loss after dextran sodium sulfate (DSS) administration

• increased incidence of diarrhea and rectal bleeding after DSS administration

• more severely shortened colon after DSS administration

• increased intestinal tissue damage after DSS administration

• increased bacterial load in mesenteric lymph node and colon after DSS administration

increased susceptibility to colitis induced morbidity/mortality ( J:267497 )

• after dextran sodium sulfate (DSS) administration

immune system

increased susceptibility to induced colitis ( J:267497 )

• increased, and earlier onset of, weight loss after dextran sodium sulfate (DSS) administration

• increased incidence of diarrhea and rectal bleeding after DSS administration

• more severely shortened colon after DSS administration

• increased intestinal tissue damage after DSS administration

• increased bacterial load in mesenteric lymph node and colon after DSS administration

increased susceptibility to colitis induced morbidity/mortality ( J:267497 )

• after dextran sodium sulfate (DSS) administration

increased neutrophil cell number ( J:267497 )

• increased Cd11b+ Ly6g+ neutrophil frequency during dextran sodium sulfate (DSS)-induced colitis

abnormal cytokine secretion ( J:267497 )

• increased expression of Il1a, Il1b, Il6, Cxcl1, Cxcl2, Csf3 during dextran sodium sulfate (DSS)-induced colitis

• normal expression of Il4, Il10, Il12, Il17, Tnfa, Gzma, Gzmb, Stat4, Gata3, Rorc, Foxp3 during DSS-induced colitis

increased susceptibility to bacterial infection ( J:231298 , J:267497 )

• increased pathogen load in liver and spleen after intravenous injection of L. monocytogenes (J:231298)

• increased bacterial load in mesenteric lymph node and colon during dextran sodium sulfate (DSS)-induced colitis (J:267497)

• normal bacterial load in spleen during DSS-induced colitis (J:267497)

hematopoietic system

hematopoietic system phenotype ( J:267497 )

N • normal Cd3+, Cd4+ and Cd8+ T cells during dextran sodium sulfate (DSS)-induced colitis during dextran sodium sulfate (DSS)-induced colitis

N • normal Cd80, Cd86 and Mog expression in Cd11c+ bone marrow dendritic cells (BMDCs) during DSS-induced colitis

increased neutrophil cell number ( J:267497 )

• increased Cd11b+ Ly6g+ neutrophil frequency during dextran sodium sulfate (DSS)-induced colitis

mortality/aging

increased susceptibility to colitis induced morbidity/mortality ( J:267497 )

• after dextran sodium sulfate (DSS) administration