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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ezh2tm1.1Nesh
targeted mutation 1.1, Norman E Sharpless
MGI:6393578
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ezh2tm1.1Nesh/Ezh2+
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:6393679
cn2
 		Ezh2tm1.1Nesh/Ezh2tm1.1Nesh
Cd19tm1(cre)Cgn/Cd19+ 		involves: 129 * 129P2/OlaHsd * C57BL/6 MGI:6393694
cn3
 		Braftm1Mmcm/Braf+
Ezh2tm1.1Nesh/Ezh2+
Tg(Tyr-cre/ERT2)13Bos/0 		involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB MGI:6393921
cn4
 		Ezh2tm1.1Nesh/Ezh2+
Nrastm1.1Nesh/Nras+
Tg(Tyr-cre/ERT2)13Bos/0 		involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB MGI:6393932
cn5
 		Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh
Ezh2tm1.1Nesh/Ezh2+
Nrastm1.1Nesh/Nras+
Tg(Tyr-cre/ERT2)13Bos/0 		involves: 129 * 129S4/SvJae * 129P2/OlaHsd * C57BL/6 * FVB MGI:6393935


Genotype
MGI:6393679
cn1
Allelic
Composition		 Ezh2tm1.1Nesh/Ezh2+
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Ezh2tm1.1Nesh mutation (1 available); any Ezh2 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:239472 )
• median survival of 1 year

neoplasm
increased leukemia incidence ( J:239472 )
• about 50% of mice show frank leukemia and/or hepatic involvement
increased B cell derived lymphoma incidence ( J:239472 )
• mice develop B cell lymphoma with a median survival of 1 year
• tumors show a CD45+B220+CD19+IgM+CD43+CD5+ immunophenotype
• mice treated with JQEZ5, an S-5'adenosyl-l-methionine (SAM)-competitive pyridinone inhibitor, for 6 days show completely cleared malignant population from the spleen without depleting normal B cells

immune system
abnormal spleen morphology ( J:239472 )
• tumor-bearing mice show disruption of the splenic architecture
abnormal spleen white pulp morphology ( J:239472 )
• tumor-bearing mice show expansion of abnormal, large lymphoid cells in the white pulp

hematopoietic system
abnormal spleen morphology ( J:239472 )
• tumor-bearing mice show disruption of the splenic architecture
abnormal spleen white pulp morphology ( J:239472 )
• tumor-bearing mice show expansion of abnormal, large lymphoid cells in the white pulp

growth/size/body
enlarged spleen ( J:239472 )

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
B-cell lymphoma DOID:707 J:239472




Genotype
MGI:6393694
cn2
Allelic
Composition		 Ezh2tm1.1Nesh/Ezh2tm1.1Nesh
Cd19tm1(cre)Cgn/Cd19+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Ezh2tm1.1Nesh mutation (1 available); any Ezh2 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased B cell derived lymphoma incidence ( J:239472 )
• development of B cell lymphoma with kinetics and tumor immunophenotype nearly identical to heterozygous conditional mutants

immune system
enlarged lymph nodes ( J:239472 )
• lymphadenopathy with an infiltration of abnormal B220lowMac2low B cells

hematopoietic system

growth/size/body
enlarged spleen ( J:239472 )




Genotype
MGI:6393921
cn3
Allelic
Composition		 Braftm1Mmcm/Braf+
Ezh2tm1.1Nesh/Ezh2+
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braftm1Mmcm mutation (3 available); any Braf mutation (60 available)
Ezh2tm1.1Nesh mutation (1 available); any Ezh2 mutation (72 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased melanoma incidence ( J:239472 )
• tamoxifen-treated mice show accelerated tumorigenesis of unpigmented, nonmetastatic melanoma compared to single Braf conditional mutants




Genotype
MGI:6393932
cn4
Allelic
Composition		 Ezh2tm1.1Nesh/Ezh2+
Nrastm1.1Nesh/Nras+
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2tm1.1Nesh mutation (1 available); any Ezh2 mutation (72 available)
Nrastm1.1Nesh mutation (2 available); any Nras mutation (44 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:239472 )
N
• tamoxifen-treated mice do not show acceleration of melanomagenesis and do not form melanoma compared to single Nras conditional mutants




Genotype
MGI:6393935
cn5
Allelic
Composition		 Cdkn2atm2.1Nesh/Cdkn2atm2.1Nesh
Ezh2tm1.1Nesh/Ezh2+
Nrastm1.1Nesh/Nras+
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background		 involves: 129 * 129S4/SvJae * 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm2.1Nesh mutation (4 available); any Cdkn2a mutation (67 available)
Ezh2tm1.1Nesh mutation (1 available); any Ezh2 mutation (72 available)
Nrastm1.1Nesh mutation (2 available); any Nras mutation (44 available)
Tg(Tyr-cre/ERT2)13Bos mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased melanoma incidence ( J:239472 )
• tamoxifen-treated mice develop melanoma similarly to conditional Nras and Cdkn2a double mutants




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory