Phenotypes associated with this allele

• Allele Symbol: Mir511^em1Clib
• Allele Name: endonuclease-mediated mutation 1, Claude Libert
• Allele ID: MGI:6393612
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir511^em1Clib/Mir511^em1Clib	C57BL/6J-Mir511^em1Clib	MGI:7611981

Genotype
MGI:7611981

hm1

• Allelic Composition: Mir511^em1Clib/Mir511^em1Clib
• Genetic Background: C57BL/6J-Mir511^em1Clib

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:345580 )

N • colons show no infiltration of granulocytes/monocytes, ulceration, or fibrosis and appear healthy

decreased susceptibility to induced colitis ( J:345580 )

• mice are protected against Dextran Sodium Sulfate (DSS)-induced colitis, showing a reduction in body weight loss, disease activity index, colitis histology index score, inflammation, and colonic cytokine and chemokine levels, however no differences are seen in spleen weight or colon weight/length ratio

• mice with DSS-induced colitis show lower percentage of monocytes and a higher percentage of maturing monocytes in inflamed colons compared to controls, while no difference is seen for neutrophils, dendritic cells, and macrophage populations

hematopoietic system

abnormal macrophage physiology ( J:345580 )

• cultured bone marrow derived macrophages differentiated into M2 macrophages show a reduction in TNF-alpha and IL-6 response when stimulated with LPS compared to wild-type M2 macrophages, indicating that LPS-mediated cytokine responses are reduced in macrophages

• Polyinosinic:polycytidylic acid (Poly I:C)-mediated, but not Zymosan-mediated, cytokine responses are reduced in macrophages

immune system

decreased susceptibility to induced colitis ( J:345580 )

• mice are protected against Dextran Sodium Sulfate (DSS)-induced colitis, showing a reduction in body weight loss, disease activity index, colitis histology index score, inflammation, and colonic cytokine and chemokine levels, however no differences are seen in spleen weight or colon weight/length ratio

• mice with DSS-induced colitis show lower percentage of monocytes and a higher percentage of maturing monocytes in inflamed colons compared to controls, while no difference is seen for neutrophils, dendritic cells, and macrophage populations

abnormal macrophage physiology ( J:345580 )

• cultured bone marrow derived macrophages differentiated into M2 macrophages show a reduction in TNF-alpha and IL-6 response when stimulated with LPS compared to wild-type M2 macrophages, indicating that LPS-mediated cytokine responses are reduced in macrophages

• Polyinosinic:polycytidylic acid (Poly I:C)-mediated, but not Zymosan-mediated, cytokine responses are reduced in macrophages