All Phenotypes Rnu11<tm1.1Rank> MGI Mouse

nervous system

• significantly reduced number of RGCs in pallium of E13 and E14 embryos

• normal number of RGCs in pallium of E12 embryos

abnormal pallium development ( J:266583 )

• significantly thinner than wildtype in E14 embryos

• normal thickness in E13 embryos

absent hippocampus ( J:266583 )

• significantly reduced number of proliferating NPCs in pallium of E13 and E14 embryos

• significantly reduced number of intermediate progenitor cells (IPCs) in pallium of E13 and E14 embryos

• significantly reduced number of RGCs in pallium of E13 and E14 embryos

• normal number of proliferating NPCs in pallium of E12 embryos

• normal number of IPCs in pallium of E12 embryos

• normal number of RGCs in pallium of E12 embryos

decreased neuron number ( J:266583 )

• significantly reduced number of neurons in pallium of E14 embryos

• normal number of neurons in pallium of E12 and E13 embryos

cellular

increased cell death ( J:266583 )

• in pallium of E12-14 embryos

• significantly reduced number of RGCs in pallium of E13 and E14 embryos

• normal number of RGCs in pallium of E12 embryos

growth/size/body

microcephaly ( J:266583 )

• owing to decrease in number of neuronal progenitor cells

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24