About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sf3b4em1Mce
endonuclease-mediated mutation 1, Tokyo Medical and Dental University
MGI:6393980
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sf3b4em1Mce/Sf3b4em1Mce C57BL/6J-Sf3b4em1Mce MGI:6393987
ht2
 		Sf3b4em1Mce/Sf3b4+ C57BL/6J-Sf3b4em1Mce MGI:6393988


Genotype
MGI:6393987
hm1
Allelic
Composition		 Sf3b4em1Mce/Sf3b4em1Mce
Genetic
Background		 C57BL/6J-Sf3b4em1Mce
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sf3b4em1Mce mutation (0 available); any Sf3b4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:285287 )
• mice die between late blastocyst and early implantation




Genotype
MGI:6393988
ht2
Allelic
Composition		 Sf3b4em1Mce/Sf3b4+
Genetic
Background		 C57BL/6J-Sf3b4em1Mce
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sf3b4em1Mce mutation (0 available); any Sf3b4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
abnormal neurocranium morphology ( J:285287 )
• flat at P0 with somewhat flattened frontal, parietal, squamosal, and interparietal bones
• however, bones exhibit normal thickness
abnormal parietal bone morphology ( J:285287 )
• somewhat flattened with shortened distance between the apical edge of the left and right parietal bones
increased rib number ( J:285287 )
• ectopic ribs on the seventh cervical vertebra
thoracic vertebral transformation ( J:285287 )
• T1 to T2
• however, T13 retains is identity
cervical vertebral transformation ( J:285287 )
• ectopic ribs on the seventh cervical vertebra
decreased lumbar vertebrae number ( J:285287 )
• L6 is transformed to S1
lumbar vertebral transformation ( J:285287 )
• L6 is transformed to S1

nervous system
decreased neuronal precursor proliferation ( J:285287 )
• of PHH3positive cell in the forebrain

growth/size/body
flat head ( J:285287 )
decreased body size ( J:285287 )
• up to 8weeks of age

craniofacial
abnormal neurocranium morphology ( J:285287 )
• flat at P0 with somewhat flattened frontal, parietal, squamosal, and interparietal bones
• however, bones exhibit normal thickness
abnormal parietal bone morphology ( J:285287 )
• somewhat flattened with shortened distance between the apical edge of the left and right parietal bones

cellular
decreased neuronal precursor proliferation ( J:285287 )
• of PHH3positive cell in the forebrain




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory