All Phenotypes Cchcr1<em1Aoka> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cchcr1^em1Aoka
endonuclease-mediated mutation 1, Akira Oka
MGI:6394064

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cchcr1^em1Aoka/Cchcr1^em1Aoka	C57BL/6NJcl-Cchcr1^em1Aoka	MGI:6782396
ht2	Cchcr1^em1Aoka/Cchcr1⁺	C57BL/6NJcl-Cchcr1^em1Aoka	MGI:6782398

Allelic Composition	Cchcr1^em1Aoka/Cchcr1^em1Aoka
Genetic Background	C57BL/6NJcl-Cchcr1^em1Aoka

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cchcr1^em1Aoka mutation (0 available); any Cchcr1 mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

integument phenotype ( J:309941 )

N	• normal presence of hair follicles in alopecic areas

alopecia ( J:309941 )

• hair loss patches after birth in 55% of mice

• number and size of hair loss patches increases over time

• varied location of hair loss

brittle hair ( J:309941 )

• broken hair in alopecic areas

abnormal hair shaft morphology ( J:309941 )

• tapered hair in alopecic areas

abnormal hair cuticle ( J:309941 )

• abnormal (irregular) cuticle morphology in both normal and alopecic areas but more pronounced in latter

immune system

immune system phenotype ( J:309941 )

N	• no lymphocyte infiltration in alopecic areas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
alopecia areata		DOID:986	OMIM:104000 OMIM:610753	J:309941

Allelic Composition	Cchcr1^em1Aoka/Cchcr1⁺
Genetic Background	C57BL/6NJcl-Cchcr1^em1Aoka