Analysis Tools
reproductive system
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• seminiferous tubules show a mosaic pattern in which about half of the tubules are largely devoid of germ cells, apart from a ring of spermatogonia adjacent to the basal membrane, and the remaining tubules show maturation arrest at the pachytene stage of spermatogenesis
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small testis
(
J:269011
)
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• seminiferous tubules show a mosaic pattern in which about half of the tubules are largely devoid of germ cells, apart from a ring of spermatogonia adjacent to the basal membrane, and the remaining tubules show maturation arrest at the pachytene stage of spermatogenesis
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endocrine/exocrine glands
small testis
(
J:269011
)
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homeostasis/metabolism
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• MEFs show a defect in stalled fork protection
• however, homology-directed repair is normal
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cellular
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• seminiferous tubules show a mosaic pattern in which about half of the tubules are largely devoid of germ cells, apart from a ring of spermatogonia adjacent to the basal membrane, and the remaining tubules show maturation arrest at the pachytene stage of spermatogenesis
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• MEFs are hypersensitive to the DNA inter-strand crosslinking agent mitomycin C and the PARP inhibitor olaparib, indicating hypersensitivity to genotoxic agents
• MEFs accumulate chromosomal rearrangements in response to genotoxic stress induced by mitomycin C
• however, MEFs show normal response to ionizing radiation
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• MEFs show a defect in stalled fork protection
• however, homology-directed repair is normal
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neoplasm
