Analysis Tools
growth/size/body
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• weight is about 10% lower than in controls at 1 month of age and this difference in weight becomes less pronounced with age, with 4-month-old mice weighing about 5% less than controls
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skeleton
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• bone-marrow derived macrophage cultures show increased osteoclast formation
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• calvarial osteoblasts grown in culture exhibit a 1.5 higher proliferation rate than wild-type cells
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• osteoclast surface/bone surface is increased in males at 1 month of age
• however, osteoclast number/bone perimeter is not affected and osteoclast surface and osteoclast number are not affected in 4-month-old male femurs
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• 1-month-old mice exhibit cancellous and cortical bone osteopenia
• during maturation, cancellous and cortical bones are restored in females but not in males, which exhibit cancellous bone osteopenia at 4 months of age
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• femora of males and females show decreased bone volume/tissue volume at 1 month of age
• at 4 months of age, males show decreased bone volume/tissue volume in femurs
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• 35-60% decrease in cancellous bone volume in 1-month-old mice
• at 4 months of age, males, but not females, continue to show a decrease in cancellous bone volume of about 30%
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• cortical bone is thin and porous in 1-month old mice, however total bone area is not different
• however, by 4 months of age, cortical bone is not altered
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• approximate 2-fold increase in the number of osteoblasts and in osteoblast surface/bone surface in femurs at 1-month of age
• at 4 months of age, males show a 60% increase in osteoblast number in femurs
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• 13-33% increase in osteocyte cell density in femurs at 1-month of age
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• mice show a predominance of rodlike trabeculae
• however, trabecular thickness is normal
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• in males and females at 1-month and 4-months of age
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• increase in mineral apposition rate in males at 1 month of age, with a nonsignificant increase in bone formation rate
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• at 4 months of age, males show elevated bone formation rate
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hematopoietic system
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• bone-marrow derived macrophage cultures show increased osteoclast formation
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• osteoclast surface/bone surface is increased in males at 1 month of age
• however, osteoclast number/bone perimeter is not affected and osteoclast surface and osteoclast number are not affected in 4-month-old male femurs
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immune system
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• bone-marrow derived macrophage cultures show increased osteoclast formation
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• osteoclast surface/bone surface is increased in males at 1 month of age
• however, osteoclast number/bone perimeter is not affected and osteoclast surface and osteoclast number are not affected in 4-month-old male femurs
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cellular
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• bone-marrow derived macrophage cultures show increased osteoclast formation
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• calvarial osteoblasts grown in culture exhibit a 1.5 higher proliferation rate than wild-type cells
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behavior/neurological
| N |
• mice exhibit no obvious neurological alternations
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