Phenotypes associated with this allele

• Allele Symbol: Relt^tm1Hlee
• Allele Name: targeted mutation 1, Ho Lee
• Allele ID: MGI:6400520
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Relt^tm1Hlee/Relt^tm1Hlee	Not Specified	MGI:6400556

Genotype
MGI:6400556

hm1

• Allelic Composition: Relt^tm1Hlee/Relt^tm1Hlee
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased T cell proliferation ( J:266480 )

• increased CD4+ T cell homeostatic proliferation

• normal CD8+ T cell homeostatic prolif

hematopoietic system

hematopoietic system phenotype ( J:266480 )

N • normal frequencies of CD4+ T cells, CD8+ T cells, B220+ B cells, CD3- NK1.1+ NK cells, and CD11c+ dendritic cells in lymph node and spleen

N • normal ratio of immune cell subsets in lymph node and spleen

N • normal thymocyte subpopulations in lymph node and spleen

increased T cell proliferation ( J:266480 )

• normal CD8+ T cell homeostatic prolif

• increased CD4+ T cell homeostatic proliferation

abnormal T cell morphology ( J:266480 )

• increased accumulation of activated CD8+ T cells

immune system

immune system phenotype ( J:266480 )

N • normal frequencies of CD4+ T cells, CD8+ T cells, B220+ B cells, CD3- NK1.1+ NK cells, and CD11c+ dendritic cells in lymph node and spleen

N • normal ratio of immune cell subsets in lymph node and spleen

N • normal thymocyte subpopulations in lymph node and spleen

increased T cell proliferation ( J:266480 )

• increased CD4+ T cell homeostatic proliferation

• normal CD8+ T cell homeostatic prolif

abnormal T cell morphology ( J:266480 )

• increased accumulation of activated CD8+ T cells

neoplasm

abnormal tumor susceptibility ( J:266480 )

• reduced tumor growth after injection with MC38 colon adenocarcinoma cells

• increased frequency of CD8b+ tumor-infiltrating lymphocytes 14 days after injection with MC38 colon adenocarcinoma cells

• normal tumor growth after injection with B16-F10 melanoma cells

• normal frequency of CD8b+ tumor-infiltrating lymphocytes after injection with B16-F10 melanoma cells