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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Relttm1Hlee
targeted mutation 1, Ho Lee
MGI:6400520
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Relttm1Hlee/Relttm1Hlee Not Specified MGI:6400556


Genotype
MGI:6400556
hm1
Allelic
Composition
Relttm1Hlee/Relttm1Hlee
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Relttm1Hlee mutation (0 available); any Relt mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• increased CD4+ T cell homeostatic proliferation
• normal CD8+ T cell homeostatic prolif

hematopoietic system
N
• normal frequencies of CD4+ T cells, CD8+ T cells, B220+ B cells, CD3- NK1.1+ NK cells, and CD11c+ dendritic cells in lymph node and spleen
• normal ratio of immune cell subsets in lymph node and spleen
• normal thymocyte subpopulations in lymph node and spleen
• increased CD4+ T cell homeostatic proliferation
• normal CD8+ T cell homeostatic prolif
• increased accumulation of activated CD8+ T cells

immune system
N
• normal frequencies of CD4+ T cells, CD8+ T cells, B220+ B cells, CD3- NK1.1+ NK cells, and CD11c+ dendritic cells in lymph node and spleen
• normal ratio of immune cell subsets in lymph node and spleen
• normal thymocyte subpopulations in lymph node and spleen
• increased CD4+ T cell homeostatic proliferation
• normal CD8+ T cell homeostatic prolif
• increased accumulation of activated CD8+ T cells

neoplasm
• reduced tumor growth after injection with MC38 colon adenocarcinoma cells
• increased frequency of CD8b+ tumor-infiltrating lymphocytes 14 days after injection with MC38 colon adenocarcinoma cells
• normal tumor growth after injection with B16-F10 melanoma cells
• normal frequency of CD8b+ tumor-infiltrating lymphocytes after injection with B16-F10 melanoma cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory