cellular
• increased CD4+ T cell homeostatic proliferation
• normal CD8+ T cell homeostatic prolif
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hematopoietic system
N |
• normal frequencies of CD4+ T cells, CD8+ T cells, B220+ B cells, CD3- NK1.1+ NK cells, and CD11c+ dendritic cells in lymph node and spleen
• normal ratio of immune cell subsets in lymph node and spleen
• normal thymocyte subpopulations in lymph node and spleen
|
• increased CD4+ T cell homeostatic proliferation
• normal CD8+ T cell homeostatic prolif
|
• increased accumulation of activated CD8+ T cells
|
immune system
N |
• normal frequencies of CD4+ T cells, CD8+ T cells, B220+ B cells, CD3- NK1.1+ NK cells, and CD11c+ dendritic cells in lymph node and spleen
• normal ratio of immune cell subsets in lymph node and spleen
• normal thymocyte subpopulations in lymph node and spleen
|
• increased CD4+ T cell homeostatic proliferation
• normal CD8+ T cell homeostatic prolif
|
• increased accumulation of activated CD8+ T cells
|
neoplasm
• reduced tumor growth after injection with MC38 colon adenocarcinoma cells
• increased frequency of CD8b+ tumor-infiltrating lymphocytes 14 days after injection with MC38 colon adenocarcinoma cells
• normal tumor growth after injection with B16-F10 melanoma cells
• normal frequency of CD8b+ tumor-infiltrating lymphocytes after injection with B16-F10 melanoma cells
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