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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mef2btm1.1Rdf
targeted mutation 1.1, Riccardo Dalla-Favera
MGI:6400970
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf
Mef2ctm2Eno/Mef2ctm2Eno 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:6401163
cn2
 		Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf 		involves: 129P2/OlaHsd * C57BL/6 MGI:6401139
cn3
 		Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:6401143
cn4
 		Ighg1tm1(cre)Cgn/0
Mef2btm2Rdf/Mef2btm1.1Rdf 		involves: 129P2/OlaHsd * C57BL/6 MGI:6401145


Genotype
MGI:6401163
cn1
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf
Mef2ctm2Eno/Mef2ctm2Eno
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2btm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
Mef2ctm2Eno mutation (0 available); any Mef2c mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased germinal center B cell number ( J:265465 )
• 14 days after immunization with sheep red blood cells (SRBCs)

immune system
decreased germinal center B cell number ( J:265465 )
• 14 days after immunization with sheep red blood cells (SRBCs)




Genotype
MGI:6401139
cn2
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2btm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal mature B cell morphology ( J:265465 )
• decreased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• smaller GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal follicular and marginal zone B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
decreased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ

immune system
abnormal mature B cell morphology ( J:265465 )
• decreased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• smaller GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal follicular and marginal zone B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
decreased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ




Genotype
MGI:6401143
cn3
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2btm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased germinal center B cell number ( J:265465 )
• modest reduction in number 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ

immune system
decreased germinal center B cell number ( J:265465 )
• modest reduction in number 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ




Genotype
MGI:6401145
cn4
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm2Rdf/Mef2btm1.1Rdf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2btm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
Mef2btm2Rdf mutation (0 available); any Mef2b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)

immune system
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory