About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mef2btm1.1Rdf
targeted mutation 1.1, Riccardo Dalla-Favera
MGI:6400970
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf
Mef2ctm2Eno/Mef2ctm2Eno 		involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:6401163
cn2
 		Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf 		involves: 129P2/OlaHsd * C57BL/6 MGI:6401139
cn3
 		Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:6401143
cn4
 		Ighg1tm1(cre)Cgn/0
Mef2btm2Rdf/Mef2btm1.1Rdf 		involves: 129P2/OlaHsd * C57BL/6 MGI:6401145


Genotype
MGI:6401163
cn1
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf
Mef2ctm2Eno/Mef2ctm2Eno
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2btm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
Mef2ctm2Eno mutation (0 available); any Mef2c mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased germinal center B cell number ( J:265465 )
• 14 days after immunization with sheep red blood cells (SRBCs)

immune system
decreased germinal center B cell number ( J:265465 )
• 14 days after immunization with sheep red blood cells (SRBCs)




Genotype
MGI:6401139
cn2
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2btm1.1Rdf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2btm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal mature B cell morphology ( J:265465 )
• decreased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• smaller GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal follicular and marginal zone B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
decreased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ

immune system
abnormal mature B cell morphology ( J:265465 )
• smaller GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• decreased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• normal follicular and marginal zone B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
decreased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ




Genotype
MGI:6401143
cn3
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm1.1Rdf/Mef2b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2btm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased germinal center B cell number ( J:265465 )
• modest reduction in number 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ

immune system
decreased germinal center B cell number ( J:265465 )
• modest reduction in number 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ




Genotype
MGI:6401145
cn4
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm2Rdf/Mef2btm1.1Rdf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2btm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
Mef2btm2Rdf mutation (0 available); any Mef2b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)

immune system
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory