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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mef2btm2Rdf
targeted mutation 2, Riccardo Dalla-Favera
MGI:6400973
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ighg1tm1(cre)Cgn/0
Mef2btm2Rdf/Mef2btm1.1Rdf 		involves: 129P2/OlaHsd * C57BL/6 MGI:6401145
cn2
 		Ighg1tm1(cre)Cgn/0
Mef2btm2Rdf/Mef2b+ 		involves: 129P2/OlaHsd * C57BL/6 MGI:6401148
cn3
 		Mef2btm2Rdf/Mef2b+
Tg(BCL2/IGH)M23Tjd/0
Tg(Cr2-cre)3Cgn/0 		involves: C3H/He * C57BL/6 MGI:6401158
cn4
 		Mef2btm2Rdf/Mef2b+
Tg(Cr2-cre)3Cgn/0 		involves: C57BL/6 MGI:6401150


Genotype
MGI:6401145
cn1
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm2Rdf/Mef2btm1.1Rdf
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2btm1.1Rdf mutation (0 available); any Mef2b mutation (22 available)
Mef2btm2Rdf mutation (0 available); any Mef2b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)

immune system
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)




Genotype
MGI:6401148
cn2
Allelic
Composition		 Ighg1tm1(cre)Cgn/0
Mef2btm2Rdf/Mef2b+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1tm1(cre)Cgn mutation (3 available); any Ighg1 mutation (28 available)
Mef2btm2Rdf mutation (0 available); any Mef2b mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ and increased number in LZ

immune system
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• larger GC B cells 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)
• reduced dark zone (DZ)/light zone (LZ) ratio owing to reduced number of cells in DZ and increased number in LZ




Genotype
MGI:6401158
cn3
Allelic
Composition		 Mef2btm2Rdf/Mef2b+
Tg(BCL2/IGH)M23Tjd/0
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: C3H/He * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2btm2Rdf mutation (0 available); any Mef2b mutation (22 available)
Tg(BCL2/IGH)M23Tjd mutation (0 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lymphoma incidence ( J:265465 )
• plasmablastic lymphoma (PBL) in 20% of mice at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)
increased follicular lymphoma incidence ( J:265465 )
• in 40% of mice at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)




Genotype
MGI:6401150
cn4
Allelic
Composition		 Mef2btm2Rdf/Mef2b+
Tg(Cr2-cre)3Cgn/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mef2btm2Rdf mutation (0 available); any Mef2b mutation (22 available)
Tg(Cr2-cre)3Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
enlarged spleen ( J:265465 )
• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)

immune system
enlarged spleen ( J:265465 )
• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)
abnormal mature B cell morphology ( J:265465 )
• increased GC B cell number 10 days after immunization with sheep red blood cells (SRBCs)
• normal non-GC B cell numbers 10 days after immunization with sheep red blood cells (SRBCs)
increased germinal center B cell number ( J:265465 )
• 10 days after immunization with sheep red blood cells (SRBCs)
enlarged mesenteric lymph nodes ( J:265465 )
• at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)
enlarged lymph nodes ( J:265465 )
• in 28% of mice at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

neoplasm
increased B cell derived lymphoma incidence ( J:265465 )
• at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)

growth/size/body
enlarged spleen ( J:265465 )
• observed occasionally at age 17-18 months after chronic immunization with sheep red blood cells (SRBCs)




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory