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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ddx41tm1.1Arte
targeted mutation 1.1, TaconicArtemis
MGI:6401407
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ddx41tm1.1Arte/Ddx41tm1.1Arte
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6N MGI:6401465
cn2
 		Ddx41tm1.1Arte/Ddx41tm1.1Arte
Tg(Itgax-cre)1-1Reiz/0 		involves: C57BL/6 * C57BL/6N * CBA MGI:6401463


Genotype
MGI:6401465
cn1
Allelic
Composition		 Ddx41tm1.1Arte/Ddx41tm1.1Arte
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx41tm1.1Arte mutation (0 available); any Ddx41 mutation (46 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:265023 )
N
• normal response by bone marrow-derived macrophages (BMDMs) to LPS, poly(I.C) and cGAMP
• normal percentage macrophages in peripheral blood

immune system
immune system phenotype ( J:265023 )
N
• normal percentage macrophages in peripheral blood
• normal response by bone marrow-derived macrophages (BMDMs) to LPS, poly(I.C) and cGAMP
increased susceptibility to Retroviridae infection ( J:265023 )
• lack of interferon beta surge in BMDMs from MLV (murine leukemia virus) or HIV-infected mice
• normal interferon beta surge in bone marrow dendritic cells (BMDCs) from MLV (murine leukemia virus)-infected mice




Genotype
MGI:6401463
cn2
Allelic
Composition		 Ddx41tm1.1Arte/Ddx41tm1.1Arte
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx41tm1.1Arte mutation (0 available); any Ddx41 mutation (46 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:265023 )
N
• normal percentage dendritic cells (DCs) in peripheral blood
• normal response by bone marrow DCs (BMDCs) to LPS, poly(I.C) and cGAMP

immune system
immune system phenotype ( J:265023 )
N
• normal percentage dendritic cells (DCs) in peripheral blood
• normal response by bone marrow DCs (BMDCs) to LPS, poly(I.C) and cGAMP
increased susceptibility to Retroviridae infection ( J:265023 )
• lack of interferon beta surge in BMDCs from MLV (murine leukemia virus) or HIV-infected mice
• 5x higher virus titer in spleen 16 days after inoculation of newborn pups with MLV (murine leukemia virus)
• higher infection levels in draining lymph node after subcutaneous inoculation with MLV (murine leukemia virus)
• normal interferon beta surge in bone marrow-derived macrophages (BMDMs) from MLV (murine leukemia virus)-infected mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory