About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ddx41tm1.1Arte
targeted mutation 1.1, TaconicArtemis
MGI:6401407
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ddx41tm1.1Arte/Ddx41tm1.1Arte
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * C57BL/6N MGI:6401465
cn2
 		Ddx41tm1.1Arte/Ddx41tm1.1Arte
Tg(Itgax-cre)1-1Reiz/0 		involves: C57BL/6 * C57BL/6N * CBA MGI:6401463


Genotype
MGI:6401465
cn1
Allelic
Composition		 Ddx41tm1.1Arte/Ddx41tm1.1Arte
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx41tm1.1Arte mutation (0 available); any Ddx41 mutation (46 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:265023 )
N
• normal response by bone marrow-derived macrophages (BMDMs) to LPS, poly(I.C) and cGAMP
• normal percentage macrophages in peripheral blood

immune system
immune system phenotype ( J:265023 )
N
• normal percentage macrophages in peripheral blood
• normal response by bone marrow-derived macrophages (BMDMs) to LPS, poly(I.C) and cGAMP
increased susceptibility to Retroviridae infection ( J:265023 )
• lack of interferon beta surge in BMDMs from MLV (murine leukemia virus) or HIV-infected mice
• normal interferon beta surge in bone marrow dendritic cells (BMDCs) from MLV (murine leukemia virus)-infected mice




Genotype
MGI:6401463
cn2
Allelic
Composition		 Ddx41tm1.1Arte/Ddx41tm1.1Arte
Tg(Itgax-cre)1-1Reiz/0
Genetic
Background		 involves: C57BL/6 * C57BL/6N * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx41tm1.1Arte mutation (0 available); any Ddx41 mutation (46 available)
Tg(Itgax-cre)1-1Reiz mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:265023 )
N
• normal percentage dendritic cells (DCs) in peripheral blood
• normal response by bone marrow DCs (BMDCs) to LPS, poly(I.C) and cGAMP

immune system
immune system phenotype ( J:265023 )
N
• normal percentage dendritic cells (DCs) in peripheral blood
• normal response by bone marrow DCs (BMDCs) to LPS, poly(I.C) and cGAMP
increased susceptibility to Retroviridae infection ( J:265023 )
• lack of interferon beta surge in BMDCs from MLV (murine leukemia virus) or HIV-infected mice
• 5x higher virus titer in spleen 16 days after inoculation of newborn pups with MLV (murine leukemia virus)
• higher infection levels in draining lymph node after subcutaneous inoculation with MLV (murine leukemia virus)
• normal interferon beta surge in bone marrow-derived macrophages (BMDMs) from MLV (murine leukemia virus)-infected mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory