Phenotypes associated with this allele

• Allele Symbol: Lox^tm1.1Khki
• Allele Name: targeted mutation 1.1, Kathrin H Kirsch
• Allele ID: MGI:6401446
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lox^tm1.1Khki/Lox^tm1.1Khki	involves: C57BL/6	MGI:6401448

Genotype
MGI:6401448

hm1

• Allelic Composition: Lox^tm1.1Khki/Lox^tm1.1Khki
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased incidence of tumors by chemical induction ( J:264295 )

• mice treated with slow release medroxyprogesterone acetate plus 7, 12-dimethylbenz(a)anthracene (DMBA) show enhanced susceptibility to mammary tumor development compared to treated controls, with tumors detected earlier, larger volumes and weights of mammary tumors, and greater number of lesions per bilateral gland

• however, mice do not develop spontaneous tumors and show normal mammary gland development in virgin mice and involution at day 4 of weaning is normal

decreased tumor latency ( J:264295 )

• mice treated with DMBA show accelerated mammary tumor development, with first tumor detected at week 13 compared to week 14 in DMBA-treated wild-type mice

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:264295 )

• DMBA-treated mice show shorter overall survival with a mean overall survival of 18.5 weeks compared to 20.75 weeks for controls due to breast cancer

hematopoietic system

increased lymphocyte cell number ( J:264295 )

• 61% of livers from DMBA-treated mutants show lymphocyte infiltration in the liver compared to 29% of wild-type livers

• massive all organ encompassing lymphoid infiltrations are seen in both livers and lungs in 20.8% of DMBA-treated mutants compared to 8.3% of treated wild-type mice

immune system

increased lymphocyte cell number ( J:264295 )

• 61% of livers from DMBA-treated mutants show lymphocyte infiltration in the liver compared to 29% of wild-type livers

• massive all organ encompassing lymphoid infiltrations are seen in both livers and lungs in 20.8% of DMBA-treated mutants compared to 8.3% of treated wild-type mice

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:264295 )

• mice treated with slow release medroxyprogesterone acetate plus 7, 12-dimethylbenz(a)anthracene (DMBA) show enhanced susceptibility to mammary tumor development compared to treated controls, with tumors detected earlier, larger volumes and weights of mammary tumors, and greater number of lesions per bilateral gland

• however, mice do not develop spontaneous tumors and show normal mammary gland development in virgin mice and involution at day 4 of weaning is normal