Phenotypes associated with this allele

• Allele Symbol: Tbcc^em1(IMPC)J
• Allele Name: endonuclease-mediated mutation 1, Jackson
• Allele ID: MGI:6401486
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbcc^em1(IMPC)J/Tbcc^em1(IMPC)J	C57BL/6NJ-Tbcc^em1(IMPC)J/Mmjax	MGI:6731453
ht2	Tbcc^em1(IMPC)J/Tbcc^+	C57BL/6NJ-Tbcc^em1(IMPC)J/Mmjax	MGI:7267106

Genotype
MGI:6731453

hm1

• Allelic Composition: Tbcc^em1(IMPC)J/Tbcc^em1(IMPC)J
• Genetic Background: C57BL/6NJ-Tbcc^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Tbcc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tbcc^em1(IMPC)J/Tbcc^em1(IMPC)J mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form outgrowths with apparent trophectoderm cells but limited/no inner cell mass.

embryo

absent inner cell mass ( J:279207 )

• in vitro outgrowth assays show apparent trophectoderm (TE) cells but limited/no ICM after 3 days in culture

mortality/aging

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• although blastocysts are recovered at nearly normal Mendelian ratios at E3.5 (29% versus expected 25%), no homozygous embryos can be recovered at E7.5

• however, excess resorption sites suggest that embryos elicit a decidual response in vivo

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro, blastocysts do hatch from the zona pellucida but form irregular outgrowths after 3 days in culture

Genotype
MGI:7267106

ht2

• Allelic Composition: Tbcc^em1(IMPC)J/Tbcc⁺
• Genetic Background: C57BL/6NJ-Tbcc^em1(IMPC)J/Mmjax

Data Sources

IMPC Data for Tbcc

cardiovascular system

prolonged RR interval ( J:211773 )

♂

IMPC - JAX