Phenotypes associated with this allele

• Allele Symbol: Mafb^em1Staka
• Allele Name: endonuclease-mediated mutation 1, Satoru Takahashi
• Allele ID: MGI:6401825
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mafb^em1Staka/Mafb^em1Staka	involves: C57BL/6J	MGI:6401826

Genotype
MGI:6401826

hm1

• Allelic Composition: Mafb^em1Staka/Mafb^em1Staka
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:279108 )

• mice show a 10%, 23%, and 40% lower body weight at P0, 2 weeks of age, and 4 weeks of age, respectively and remain lower

homeostasis/metabolism

increased urine microalbumin level ( J:279108 )

• increase in urine albumin/creatinine ratio already at 4 weeks of age

renal/urinary system

increased urine microalbumin level ( J:279108 )

• increase in urine albumin/creatinine ratio already at 4 weeks of age

podocyte foot process effacement ( J:279108 )

podocyte microvillus transformation ( J:279108 )

• microvillous transformation of the foot processes of podocytes is frequently seen in the Bowman's space in glomeruli in 25- and 26-week old mice

glomerulosclerosis ( J:279108 )

• mice show a higher percentage of sclerotic glomeruli

abnormal renal tubule morphology ( J:279108 )

• mice show a higher percentage of tubulointerstitial lesions

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
multicentric carpotarsal osteolysis syndrome		DOID:0111534	OMIM:166300	J:279108