Phenotypes associated with this allele

• Allele Symbol: Mir26a-1^em1Xfu
• Allele Name: endonuclease-mediated mutation 1, Xianghui Fu
• Allele ID: MGI:6402877
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Mir26a-1^em1Xfu/Mir26a-1^em1Xfu Mir26a-2^em1Xfu/Mir26a-2^em1Xfu	involves: C57BL/6	MGI:6402898

Genotype
MGI:6402898

cx1

• Allelic Composition: Mir26a-1^em1Xfu/Mir26a-1^em1Xfu; Mir26a-2^em1Xfu/Mir26a-2^em1Xfu
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreatic beta cell proliferation ( J:286108 )

• indicated by increased insulin and PCNA double-positive cells in mice fed a high-fat diet

abnormal pancreatic alpha cell morphology ( J:286108 )

• abnormal distribution in mice fed a high-fat diet

decreased pancreatic islet number ( J:286108 )

• in mice fed a high-fat diet

enlarged pancreatic islets ( J:286108 )

• in mice fed a high-fat diet

pancreatic islet hyperplasia ( J:286108 )

• in mice fed a high-fat diet

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:286108 )

• in mice fed a high-fat diet

increased circulating glucose level ( J:286108 )

• in mice fed a high-fat diet random fed

• however, mice fed standard chow exhibit normal levels

increased fasting circulating glucose level ( J:286108 )

• in mice fed a high-fat diet

increased circulating insulin level ( J:286108 )

• in fasted mice fed a high-fat diet and during glucose tolerance test

insulin resistance ( J:286108 )

• in mice fed a high-fat diet

growth/size/body

increased susceptibility to diet-induced obesity ( J:286108 )

• in mice fed a high-fat diet

cellular

increased pancreatic beta cell proliferation ( J:286108 )

• indicated by increased insulin and PCNA double-positive cells in mice fed a high-fat diet