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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		1700028K03Rikem1Jzc
endonuclease-mediated mutation 1, Zi-Jiang Chen
MGI:6402900
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		1700028K03Rikem1Jzc/1700028K03Rikem1Jzc C57BL/6-1700028K03Rikem1Jzc MGI:6402902


Genotype
MGI:6402902
hm1
Allelic
Composition		 1700028K03Rikem1Jzc/1700028K03Rikem1Jzc
Genetic
Background		 C57BL/6-1700028K03Rikem1Jzc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
1700028K03Rikem1Jzc mutation (0 available); any 1700028K03Rik mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased oocyte number ( J:285969 )
• almost not oocytes at P1however, normal oocytes are present at E17.5
absent oocytes ( J:285969 )
• at P6
azoospermia ( J:285969 )
• lack of post-meiotic cell types at P35
abnormal female meiosis I arrest ( J:285969 )
• very few normal pachytene-stage oocytes at E17.5 with severe desynapsis problems
arrest of male meiosis ( J:285969 )
• at the pachytene stage
small ovary ( J:285969 )
• underdeveloped; almost complete absence at 6 weeks of age

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:285969 )
• in spermatocyte and oocytes with impaired crossover formation secondary to instable synapsis

endocrine/exocrine glands
small ovary ( J:285969 )
• underdeveloped; almost complete absence at 6 weeks of age

cellular
decreased oocyte number ( J:285969 )
• almost not oocytes at P1however, normal oocytes are present at E17.5
absent oocytes ( J:285969 )
• at P6
azoospermia ( J:285969 )
• lack of post-meiotic cell types at P35
abnormal female meiosis I arrest ( J:285969 )
• very few normal pachytene-stage oocytes at E17.5 with severe desynapsis problems
arrest of male meiosis ( J:285969 )
• at the pachytene stage
abnormal double-strand DNA break repair ( J:285969 )
• in spermatocyte and oocytes with impaired crossover formation secondary to instable synapsis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory