Phenotypes associated with this allele

• Allele Symbol: Tle6^tm1Lil
• Allele Name: targeted mutation 1, Lei Li
• Allele ID: MGI:6402939
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tle6^tm1Lil/Tle6^tm1Lil	Not Specified	MGI:6403097
cx2	Nlrp5^tm1Zbt/Nlrp5^tm1Zbt Ooep^Gt(139A2)Cmhd/Ooep^Gt(139A2)Cmhd Tle6^tm1Lil/Tle6^tm1Lil	involves: 129S1/Sv * 129X1/SvJ	MGI:6403125

Genotype
MGI:6403097

hm1

• Allelic Composition: Tle6^tm1Lil/Tle6^tm1Lil
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

female infertility ( J:276268 )

• despite normal oogenesis and ovulation

cellular

abnormal microtubule cytoskeleton morphology ( J:276268 )

• zygotes lack a fine meshwork of cytoplasmic F-actin resulting in acentric spindle position

abnormal mitotic spindle morphology ( J:276268 )

• acentric spindle localization

embryo

failure of zygotic cell division ( J:276268 )

• progression from one- to two-cell embryos is delayed 4 to 6 hours with only fragmented cytoplasmic blebs at E2.5 and E3.5

• asymmetric division

Genotype
MGI:6403125

cx2

• Allelic Composition: Nlrp5^tm1Zbt/Nlrp5^tm1Zbt; Ooep^{Gt(139A2)Cmhd}/Ooep^{Gt(139A2)Cmhd}; Tle6^tm1Lil/Tle6^tm1Lil
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

cellular

abnormal mitotic spindle morphology ( J:276268 )

• zygotes exhibit mitotic spindle that are dysmorphic, smaller and displaced from the cell center

embryo

failure of zygotic cell division ( J:276268 )

• asymmetric division