Phenotypes associated with this allele

• Allele Symbol: Sell^tm1.1Rpmc
• Allele Name: targeted mutation 1.1, Rodger P McEver
• Allele ID: MGI:6403119
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sell^tm1.1Rpmc/Sell^tm1.1Rpmc	involves: 129S1/Sv * C57BL/6J * FVB/N	MGI:6403151

Genotype
MGI:6403151

hm1

• Allelic Composition: Sell^tm1.1Rpmc/Sell^tm1.1Rpmc
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:249558 )

N • normal homing of splenocytes to lymph nodes

N • normal cellularity of bone marrow, thymus, spleen and lymph nodes and normal peripheral blood count

abnormal granulocyte physiology ( J:249558 )

• increased phagocytosis of bacteria by peripheral blood neutrophils

• increased clearing of bacteria in peritoneum by peripheral blood neutrophils after IP injection of E. coli

abnormal neutrophil physiology ( J:249558 )

• peripheral blood neutrophils are primed

• normal bone marrow neutrophils

immune system

immune system phenotype ( J:249558 )

N • normal cellularity of bone marrow, thymus, spleen and lymph nodes

N • normal homing of splenocytes to lymph nodes

abnormal granulocyte physiology ( J:249558 )

• increased phagocytosis of bacteria by peripheral blood neutrophils

• increased clearing of bacteria in peritoneum by peripheral blood neutrophils after IP injection of E. coli

abnormal neutrophil physiology ( J:249558 )

• peripheral blood neutrophils are primed

• normal bone marrow neutrophils

increased inflammatory response ( J:249558 )

• increased clearing of bacteria in peritoneum by peripheral blood neutrophils after IP injection of E. coli

• increased phagocytosis of bacteria by peripheral blood neutrophils

• increased capability of peripheral blood neutrophils to produce reactive oxygen species (ROS) in response to agonist

• increased and prolonged ear swelling after application of croton oil

• normal mobilization of neutrophils to ears after application of croton oil

• normal mobilization of neutrophils to peritoneum after IP injection of E. coli

homeostasis/metabolism

increased susceptibility to induced thrombosis ( J:249558 )

• larger thrombi after reducing blood flow through inferior vena cava ligation

mortality/aging

mortality/aging ( J:249558 )

N • healthy; no obvious phenotype

reproductive system

reproductive system phenotype ( J:249558 )

N • fertile