Phenotypes associated with this allele

• Allele Symbol: Uqcrc1^tm1Zzuo
• Allele Name: targeted mutation 1, Zhiyi Zuo
• Allele ID: MGI:6403206
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Uqcrc1^tm1Zzuo/Uqcrc1^tm1Zzuo	involves: 129P2/OlaHsd * C57BL/6N	MGI:6403267
ht2	Uqcrc1^tm1Zzuo/Uqcrc1^+	involves: 129P2/OlaHsd * C57BL/6N	MGI:6403269

Genotype
MGI:6403267

hm1

• Allelic Composition: Uqcrc1^tm1Zzuo/Uqcrc1^tm1Zzuo
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:285933 )

• no pups born

• no embryos (0/28) at E15.5, 1 of 39 at E9.5, 2 of 23 at E7.5 and 6 of 46 blastocysts at E3.5; all malformed and/or underdeveloped

Genotype
MGI:6403269

ht2

• Allelic Composition: Uqcrc1^tm1Zzuo/Uqcrc1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

behavior/neurological

abnormal behavior ( J:285933 )

• less time spent with novel object

• time to find target on test day 4 in Barnes maze test significantly less reduced than wildtype

• longer time to identify target 1 and 8 days after testing in Barnes maze test

• normal behavior in open field test

impaired spatial learning ( J:285933 )

• time to find target on test day 4 in Barnes maze test significantly less reduced than wildtype

• longer time to identify target 1 and 8 days after testing in Barnes maze test

abnormal response to novel object ( J:285933 )

• less time spent with novel object

nervous system

increased susceptibility to ischemic brain injury ( J:285933 )

• larger infarct brain volume after brain hypoxia

• poorer neurological deficit score after brain hypoxia or middle cerebral arterial occlusion (MCAO)

growth/size/body

growth/size/body region phenotype ( J:285933 )

N • normal appearance

N • normal body weight at age 3 months

N • normal sex-specific body weight gain with age

homeostasis/metabolism

increased susceptibility to ischemic brain injury ( J:285933 )

• larger infarct brain volume after brain hypoxia

• poorer neurological deficit score after brain hypoxia or middle cerebral arterial occlusion (MCAO)

cardiovascular system

cardiovascular system phenotype ( J:285933 )

N • normal heart rate and mean arterial blood pressure

reproductive system

reproductive system phenotype ( J:285933 )

N • fertile