Phenotypes associated with this allele

• Allele Symbol: Usp49^em1Gpt
• Allele Name: endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
• Allele ID: MGI:6403288
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp49^em1Gpt/Usp49^em1Gpt	involves: C57BL/6NGpt	MGI:6403316

Genotype
MGI:6403316

hm1

• Allelic Composition: Usp49^em1Gpt/Usp49^em1Gpt
• Genetic Background: involves: C57BL/6NGpt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:285681 )

N • normal numbers and percentages of immune cells in spleen, thymus and lymph

N • normal bone marrow cell differentiation

homeostasis/metabolism

increased circulating interferon-beta level ( J:285681 )

• in serum 12 h after i.v. injection of HSV-1

increased circulating interleukin-6 level ( J:285681 )

• in serum 12 h after i.v. injection of HSV-1

immune system

immune system phenotype ( J:285681 )

N • normal numbers and percentages of immune cells in spleen, thymus and lymph nodes

N • normal bone marrow cell differentiation

increased circulating interferon-beta level ( J:285681 )

• in serum 12 h after i.v. injection of HSV-1

increased circulating interleukin-6 level ( J:285681 )

• in serum 12 h after i.v. injection of HSV-1

increased interferon-beta secretion ( J:285681 )

• by lymphatic fibroblasts (MLFs) and bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs) after stimulation with HSV-1, cytoplasmic DNA, or cGAMP

• normal secretion by MLFs, BMDMs and BMDCs after stimulation with SeV

increased interleukin-6 secretion ( J:285681 )

• normal secretion by MLFs, BMDMs and BMDCs after stimulation with SeV

• by lymphatic fibroblasts (MLFs) and bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs) after stimulation with HSV-1, cytoplasmic DNA, or cGAMP

decreased susceptibility to Herpesvirales infection ( J:285681 )

• suppressed replication of HSV-1 in lymphatic fibroblasts (MLFs) and bone marrow-derived macrophages (BMDMs) and dendritic cells (BMDCs)

• suppressed replication of HSV-1 in brain 4 days after i.v. injection of HSV-1

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:285681 )

• higher survival rate and later onset of death after i.v. injection of HSV-1

mortality/aging

mortality/aging ( J:285681 )

N • pups born at expected Mendelian ratio

decreased susceptibility to Herpesvirales infection induced morbidity/mortality ( J:285681 )

• higher survival rate and later onset of death after i.v. injection of HSV-1