Phenotypes associated with this allele

• Allele Symbol: Mir338^em1Zchn
• Allele Name: endonuclease-mediated mutation 1, Zhi Chen
• Allele ID: MGI:6403348
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mir338^em1Zchn/Mir338^em1Zchn	C57BL/6-Mir338^em1Zchn	MGI:6403350

Genotype
MGI:6403350

hm1

• Allelic Composition: Mir338^em1Zchn/Mir338^em1Zchn
• Genetic Background: C57BL/6-Mir338^em1Zchn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

decreased osteoclast cell number ( J:285968 )

increased trabecular bone volume ( J:285968 )

• in intact mice

• following ovariectomy, bone volume is equivalent to sham-treated wild-type mice

increased trabecular bone thickness ( J:285968 )

• in intact mice

immune system

decreased osteoclast cell number ( J:285968 )

hematopoietic system

decreased osteoclast cell number ( J:285968 )

abnormal bone marrow cell physiology ( J:285968 )

• harvested bone marrow stromal cells treated with osteogenic induction medium exhibit increased number of mineralization nodules compared with control cells