Phenotypes associated with this allele

• Allele Symbol: Rnf43^em2Mage
• Allele Name: endonuclease-mediated mutation 2, Markus Gerhard
• Allele ID: MGI:6403354
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rnf43^em2Mage/Rnf43^em2Mage	Not Specified	MGI:6403439

Genotype
MGI:6403439

hm1

• Allelic Composition: Rnf43^em2Mage/Rnf43^em2Mage
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell nucleus morphology ( J:285428 )

• increased nuclear enlargement and hyperchromasia and prominent nuclei in stomach cells after 6-month infection with H. pylori

digestive/alimentary system

digestive/alimentary phenotype ( J:276360 )

N • normal intestinal and colon epithelium morphology and cell proliferation at age 12, 24 and 40 weeks

abnormal stomach glandular region morphology ( J:276360 )

• multifocal hyperplasia at age 4 weeks

• hyperplasia with cellular atypia and thicker mucosa at age 24 and 40 weeks

abnormal stomach wall morphology ( J:276360 , J:285428 )

• multifocal hyperplasia at age 4 weeks (J:276360)

• hyperplasia with cellular atypia and thicker mucosa at age 24 and 40 weeks (J:276360)

• increased hyperplasia after 6-month infection with H. pylori (J:285428)

abnormal stomach mucosa morphology ( J:276360 )

• thicker mucosa at age 24 and 40 weeks

gastric metaplasia ( J:285428 )

• throughout corpus of stomach after 6-month infection with H. pylori

• multifocal metaplasia in corpus of stomach of uninfected mice

• no metaplasia in antrum (forestomach) in infected or uninfected mice

stomach inflammation ( J:285428 )

• more severe gastritis after 6-month infection with H. pylori

• higher lymphocyte infiltration after 6-month infection with H. pylori

• highly proliferative lesions after 6-month infection with H. pylori

• same level of bacterial colonization and neutrophil infiltration as wild-type after 6-month infection with H. pylori

hematopoietic system

hyperchromasia ( J:285428 )

• increased in nuclei of stomach cells after 6-month infection with H. pylori

immune system

immune system phenotype ( J:276360 )

N • no inflammation of stomach

stomach inflammation ( J:285428 )

• more severe gastritis after 6-month infection with H. pylori

• higher lymphocyte infiltration after 6-month infection with H. pylori

• highly proliferative lesions after 6-month infection with H. pylori

• same level of bacterial colonization and neutrophil infiltration as wild-type after 6-month infection with H. pylori

increased interferon-gamma secretion ( J:285428 )

• greater increase than wild-type in stomach after 6-month infection with H. pylori

mortality/aging

mortality/aging ( J:276360 )

N • viable and born at expected Mendelian ratio