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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm1(CAG-BRF1)Gu
targeted mutation 1, University of Glasgow
MGI:6403376
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0 		involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * FVB/N MGI:6403693
cn2
 		Brf1tm1Arte/Brf1tm1Arte
Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Tg(Cyp1a1-cre)1Dwi/0 		involves: 129P2/OlaHsd * C57BL/6 * CBA MGI:6403686


Genotype
MGI:6403693
cn1
Allelic
Composition		 Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Krastm4Tyj/Kras+
Trp53tm2Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(CAG-BRF1)Gu mutation (0 available); any Hprt1 mutation (1279 available)
Krastm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53tm2Tyj mutation (4 available); any Trp53 mutation (240 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:285667 )
• as in mice lacking the BRF1 knock-in

neoplasm
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• as in mice lacking the BRF1 knock-in

homeostasis/metabolism
abnormal translation ( J:285667 )
• tRNA levels are increased in the pancreas

endocrine/exocrine glands
increased pancreatic ductal adenocarcinoma incidence ( J:285667 )
• as in mice lacking the BRF1 knock-in

cellular
abnormal translation ( J:285667 )
• tRNA levels are increased in the pancreas




Genotype
MGI:6403686
cn2
Allelic
Composition		 Brf1tm1Arte/Brf1tm1Arte
Hprt1tm1(CAG-BRF1)Gu/Hprt1+
Tg(Cyp1a1-cre)1Dwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brf1tm1Arte mutation (0 available); any Brf1 mutation (23 available)
Hprt1tm1(CAG-BRF1)Gu mutation (0 available); any Hprt1 mutation (1279 available)
Tg(Cyp1a1-cre)1Dwi mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver/biliary system phenotype ( J:285667 )
N
• mice exhibit normal circulating liver enzyme, liver size, and liver cell proliferation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory