Phenotypes associated with this allele

• Allele Symbol: Usp30^tm1.1Tac
• Allele Name: targeted mutation 1.1, Taconic
• Allele ID: MGI:6403637
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp30^tm1.1Tac/Usp30^tm1.1Tac	B6(Cg)-Usp30^tm1.1Tac	MGI:6403654

Genotype
MGI:6403654

hm1

• Allelic Composition: Usp30^tm1.1Tac/Usp30^tm1.1Tac
• Genetic Background: B6(Cg)-Usp30^tm1.1Tac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal mitophagy ( J:286265 )

• 50% increase in cultured hippocampal neurons

abnormal cellular respiration ( J:286265 )

• 70% increase in basal respiration in cultured hippocampal neurons

• 30% reduction in reserve capacity in cultured hippocampal neurons

• normal ATP-linked basal respiration in cultured hippocampal neurons

homeostasis/metabolism

abnormal mitophagy ( J:286265 )

• 50% increase in cultured hippocampal neurons

mortality/aging

mortality/aging ( J:286265 )

N • viable and born at expected Mendelian ratio