Phenotypes associated with this allele

• Allele Symbol: Chdh^em1Rmps
• Allele Name: endonuclease-mediated mutation 1, Lab. for Molecular Psychiatry, RIKEN Center for Brain Science
• Allele ID: MGI:6403989
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chdh^em1Rmps/Chdh^em1Rmps	C57BL/6N-Chdh^em1Rmps	MGI:6403997

Genotype
MGI:6403997

hm1

• Allelic Composition: Chdh^em1Rmps/Chdh^em1Rmps
• Genetic Background: C57BL/6N-Chdh^em1Rmps

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased amino acid betaine level ( J:286033 )

♂ • betaine levels are reduced in the frontal cortex

♂ • supplementation of betaine via drinking water for 3 weeks increases betaine level in the brain

♂ • however, plasma betaine levels are similar to wild-type

increased circulating homocysteine level ( J:286033 )

♂ • plasma homocysteine concentration is increased

♂ • betaine supplementation reduces homocysteine concentration

♂ • however, homocysteine levels in the brain are unchanged

liver/biliary system

liver/biliary system phenotype ( J:286033 )

♂N • liver function appears normal, with unaltered plasma levels of aspartate transaminase, alanine transaminase, lactate dehydrogenase, cholinesterase, blood urea nitrogen, or creatinine

behavior/neurological

abnormal depression-related behavior ( J:286033 )

♂ • immobility time at bin 5 of the forced swim test is prolonged with total immobility showing a trend of increase suggesting remnants of depressive behavior