Phenotypes associated with this allele

• Allele Symbol: Cbfb^tm6Ppl
• Allele Name: targeted mutation 6, Pu P Liu
• Allele ID: MGI:6407110
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cbfb^tm6Ppl/Cbfb^tm6Ppl	involves: 129S/SvEv * C57BL/6	MGI:6407119
ht2	Cbfb^tm6Ppl/Cbfb^+	involves: 129S/SvEv * C57BL/6	MGI:6407120

Genotype
MGI:6407119

hm1

• Allelic Composition: Cbfb^tm6Ppl/Cbfb^tm6Ppl
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:252447 )

• mice die in mid-gestation with central nervous system hemorrhage

hematopoietic system

impaired hematopoiesis ( J:252447 )

• embryos show defective hematopoiesis with E11.5 fetal liver showing decreased cellularity and hematopoietic cells

• however, embryos do not develop a primitive hematopoiesis defect

cardiovascular system

internal hemorrhage ( J:252447 )

• central nervous system hemorrhage

Genotype
MGI:6407120

ht2

• Allelic Composition: Cbfb^tm6Ppl/Cbfb⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6

hematopoietic system

hematopoietic system phenotype ( J:252447 )

N • adult bone marrow cells show no difference from wild-type in lineage differentiation, colony forming ability, cell viability, total cell count and apoptosis

decreased B cell number ( J:252447 )

• decrease in B cells in older mice

increased myeloid cell number ( J:252447 )

• increase in Mac1+Gr1+ myeloid cells in older mice

immune system

decreased B cell number ( J:252447 )

• decrease in B cells in older mice

neoplasm

neoplasm ( J:252447 )

N • mice do not develop leukemia, even after treatment with ENU to induce additional mutations