Phenotypes associated with this allele

• Allele Symbol: Lama5^tm1.1Mggte
• Allele Name: targeted mutation 1.1, Teresa Esposito
• Allele ID: MGI:6407118
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lama5^tm1.1Mggte/Lama5^tm1.1Mggte	involves: 129P2/OlaHsd	MGI:7261450

Genotype
MGI:7261450

hm1

• Allelic Composition: Lama5^tm1.1Mggte/Lama5^tm1.1Mggte
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal hair follicle dermal papilla morphology ( J:286800 )

• flattening of the dermal papillae

abnormal hair follicle development ( J:286800 )

• complete follicles are rarely seen and rather, round-shaped structures resembling hair bulbs and hair shafts appear mostly separated in the deep and up layers of skin, respectively, suggesting a delay in the maturation of hair follicles

decreased hair follicle number ( J:286800 )

• mice exhibit reduced number of hair follicles, which are scattered or absent along the dermal-epidermal interface

abnormal epidermal-dermal junction morphology ( J:286800 )

• mice exhibit a simplification of the dermal-epidermal interface with flattening of the dermal papillae

• however, the skin does not show any pathological appearance

digestive/alimentary system

abnormal intestinal mucosa morphology ( J:286800 )

• the lamina propria along the crypts/villous axis appear more lax and wider

• the height of the lamina propria is increased

abnormal small intestinal villus morphology ( J:286800 )

• the small intestine exhibits villi with different length and caliber, club-shaped rather than uniformly cylindrical and the columnar cell layer is more discontinuous

• the basal diameter length of the villous is longer

clubbed small intestinal villi ( J:286800 )