About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slnem1Cyh
endonuclease-mediated mutation 1, Ya-Hui Chi
MGI:6407424
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slnem1Cyh/Slnem1Cyh Not Specified MGI:6407444
cx2
 		Lmnatm1Stw/Lmnatm1Stw
Slnem1Cyh/Slnem1Cyh 		involves: 129S1/Sv * C57BL/6J MGI:6407445


Genotype
MGI:6407444
hm1
Allelic
Composition		 Slnem1Cyh/Slnem1Cyh
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slnem1Cyh mutation (0 available); any Sln mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:284048 )
N
• mice exhibit normal body weight

mortality/aging
mortality/aging ( J:284048 )
N
• mice exhibit normal survival




Genotype
MGI:6407445
cx2
Allelic
Composition		 Lmnatm1Stw/Lmnatm1Stw
Slnem1Cyh/Slnem1Cyh
Genetic
Background		 involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm1Stw mutation (3 available); any Lmna mutation (84 available)
Slnem1Cyh mutation (0 available); any Sln mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:284048 )
• decreased body weight, with body weight similar to single Lmna homozygous mutants

mortality/aging
premature death ( J:284048 )
• mice show increased lethality beginning around 20 days of age and die before 60 days of age
• median lifespan is lower than in single Lmna homozygous mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory