Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pkmem1(IMPC)Bay endonuclease-mediated mutation 1, Baylor College of Medicine MGI:6414486 |
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| Summary |
3 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Pkmem1(IMPC)Bay/Pkmem1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E7.5 but not at E9.5. Embryos are smaller with no formation of the egg cylinder and no primitive streak or hallmarks of gastrulation at E7.5.
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• homozygous embryos can be recovered at E7.5 (13% versus expected 25%, n=15); no homozygous embryos are recovered at E9.5
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• no morphological hallmarks typical of gastrulating embryos are observed at E7.5
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• embryos are much smaller than controls at E7.5
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• no rudimentary egg cylinder has formed at E7.5
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• no head folds are present at E7.5
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• no embryonic node is present at E7.5
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• no morphological evidence of primitive streak formation is observed at E7.5
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• embryos are much smaller than controls at E7.5
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - BCM
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IMPC - BCM
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IMPC - BCM
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IMPC - BCM
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/09/2024 MGI 6.24 |
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