About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lsm2em1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:6414498
Summary 3 genotypes


Genotype
MGI:7720068
hm1
Allelic
Composition		 Lsm2em1(IMPC)Bay/Lsm2em1(IMPC)Bay
Genetic
Background		 C57BL/6NJ-Lsm2em1(IMPC)Bay/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lsm2em1(IMPC)Bay mutation (1 available); any Lsm2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lsm2em1(IMPC)Bay/Lsm2em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts in vitro hatch from the zona pellucida and form irregular outgrowths.

mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• blastocysts are present at E3.5 (14% versus expected 25%, n=36); no homozygous embryos are recovered at E7.5

reproductive system
abnormal embryo implantation ( J:279207 )
• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture




Genotype
MGI:7267040
hm2
Allelic
Composition		 Lsm2em1(IMPC)Bay/Lsm2em1(IMPC)Bay
Genetic
Background		 C57BL/6N-Lsm2em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lsm2em1(IMPC)Bay mutation (1 available); any Lsm2 mutation (24 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7267039
ht3
Allelic
Composition		 Lsm2em1(IMPC)Bay/Lsm2+
Genetic
Background		 C57BL/6N-Lsm2em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lsm2em1(IMPC)Bay mutation (1 available); any Lsm2 mutation (24 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory