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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lsm2em1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:6414498
Summary 3 genotypes


Genotype
MGI:7720068
hm1
Allelic
Composition		 Lsm2em1(IMPC)Bay/Lsm2em1(IMPC)Bay
Genetic
Background		 C57BL/6NJ-Lsm2em1(IMPC)Bay/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lsm2em1(IMPC)Bay mutation (1 available); any Lsm2 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Lsm2em1(IMPC)Bay/Lsm2em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts in vitro hatch from the zona pellucida and form irregular outgrowths.

mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• blastocysts are present at E3.5 (14% versus expected 25%, n=36); no homozygous embryos are recovered at E7.5

reproductive system
abnormal embryo implantation ( J:279207 )
• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture




Genotype
MGI:7267040
hm2
Allelic
Composition		 Lsm2em1(IMPC)Bay/Lsm2em1(IMPC)Bay
Genetic
Background		 C57BL/6N-Lsm2em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lsm2em1(IMPC)Bay mutation (1 available); any Lsm2 mutation (24 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7267039
ht3
Allelic
Composition		 Lsm2em1(IMPC)Bay/Lsm2+
Genetic
Background		 C57BL/6N-Lsm2em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lsm2em1(IMPC)Bay mutation (1 available); any Lsm2 mutation (24 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory