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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trmt5em1(IMPC)Bay
endonuclease-mediated mutation 1, Baylor College of Medicine
MGI:6414539
Summary 2 genotypes


Genotype
MGI:7388759
hm1
Allelic
Composition		 Trmt5em1(IMPC)Bay/Trmt5em1(IMPC)Bay
Genetic
Background		 C57BL/6N-Trmt5em1(IMPC)Bay/BayMmucd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trmt5em1(IMPC)Bay mutation (1 available); any Trmt5 mutation (17 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:7719977
hm2
Allelic
Composition		 Trmt5em1(IMPC)Bay/Trmt5em1(IMPC)Bay
Genetic
Background		 C57BL/6N-Trmt5em1(IMPC)Bay/Mmmh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trmt5em1(IMPC)Bay mutation (1 available); any Trmt5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Trmt5em1(IMPC)Bay/Trmt5em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form normal outgrowths.

mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:279207 )
• blastocysts are recovered at E3.5 (12% versus expected 25%, n=34); no homozygous embryos are recovered at E7.5 but excess resorption sites suggest that embryos elicit a decidual response in vivo
• in vitro, blastocysts hatch from the zona pellucida and form normal outgrowths after 3 days in culture




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory