Phenotypes associated with this allele

• Allele Symbol: Tbcb^em1(IMPC)Bay
• Allele Name: endonuclease-mediated mutation 1, Baylor College of Medicine
• Allele ID: MGI:6414554
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tbcb^em1(IMPC)Bay/Tbcb^em1(IMPC)Bay	C57BL/6NJ-Tbcb^em1(IMPC)Bay/Mmnc	MGI:7719956
hm2	Tbcb^em1(IMPC)Bay/Tbcb^em1(IMPC)Bay	C57BL/6N-Tbcb^em1(IMPC)Bay/BayMmucd	MGI:7267105

Genotype
MGI:7719956

hm1

• Allelic Composition: Tbcb^em1(IMPC)Bay/Tbcb^em1(IMPC)Bay
• Genetic Background: C57BL/6NJ-Tbcb^em1(IMPC)Bay/Mmnc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Tbcb^em1(IMPC)Bay/Tbcb^em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida but form irregular outgrowths in culture.

mortality/aging

embryonic lethality prior to organogenesis, complete penetrance ( J:279207 )

• blastocyst-like embryos are present at E3.5 (15% versus expected 25%, n=26); no homozygous embryos or excess resorption sites are observed at E7.5

reproductive system

abnormal embryo implantation ( J:279207 )

• in vitro outgrowth assays show that blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture

Genotype
MGI:7267105

hm2

• Allelic Composition: Tbcb^em1(IMPC)Bay/Tbcb^em1(IMPC)Bay
• Genetic Background: C57BL/6N-Tbcb^em1(IMPC)Bay/BayMmucd

Data Sources

IMPC Data for Tbcb

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - BCM