Analysis Tools|
Allele Symbol Allele Name Allele ID |
Eny2em1(IMPC)Bay endonuclease-mediated mutation 1, Baylor College of Medicine MGI:6414562 |
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| Summary |
2 genotypes
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Eny2em1(IMPC)Bay/Eny2em1(IMPC)Bay mice exhibit embryonic lethality, with embryos recovered at E3.5 as early blastocysts but not at E7.5. Blastocysts hatch from the zona pellucida and form irregular outgrowths with no obvious inner cell mass colony or trophoblast giant cells.
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• although early blastocysts are present in nearly normal Mendelian ratios at E3.5 (20% versus expected 25%), no homozygous embryos are recovered at E7.5
• however, excess resorption sites suggest that embryos elicit a decidual response in vivo
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• in vitro outgrowth assays show no obvious inner cell mass (ICM) colony after 3 days in culture
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• in vitro, no trophoblast giant cells (TGCs) are apparent after 3 days in culture
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• in vitro, blastocysts hatch from the zona pellucida but form irregular outgrowths after 3 days in culture
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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