nervous system
• 2-fold increase in the number of oligodendroglial cells in the ventral brainstem at P7 and P21
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Allele Symbol Allele Name Allele ID |
Acvr1tm1Mak targeted mutation 1, Tak W Mak MGI:6414907 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• 2-fold increase in the number of oligodendroglial cells in the ventral brainstem at P7 and P21
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
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• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin
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• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
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• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
brain glioma | DOID:0060108 | J:285841 |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• most mice succumb to spontaneous brain tumors
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• tumors are high-grade diffuse gliomas
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• most mice succumb to spontaneous brain tumors
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• tumors are high-grade diffuse gliomas
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
brain glioma | DOID:0060108 | J:285841 |
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• some mice fail to gain normal body weight and die before weaning
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• surviving mice show spasms when disrupted during rest
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• marker analysis indicates the differentiation of oligodendroglial lineage cells is blocked and neuroglial progenitors are upregulated
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• higher density of PDGFRA+ cells in brainstems
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• glial cells exhibit increased growth
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• partial early postnatal lethality
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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