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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Acvr1tm1Mak
targeted mutation 1, Tak W Mak
MGI:6414907
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+ 		involves: 129 * C57BL/6 MGI:6414954
cn2
 		Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+ 		involves: 129 * C57BL/6 * FVB/N MGI:6414961
cn3
 		Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+ 		involves: 129 * C57BL/6 * FVB/N MGI:6414964
cn4
 		Acvr1tm1Mak/Acvr1+
Olig2tm1.1(cre)Wdr/Olig2+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:6414951
cn5
 		Acvr1tm1Mak/Acvr1+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:6414958


Genotype
MGI:6414954
cn1
Allelic
Composition		 Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (44 available)
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze mutation (4 available); any Gt(ROSA)26Sor mutation (992 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased oligodendrocyte number ( J:285841 )
• 2-fold increase in the number of oligodendroglial cells in the ventral brainstem at P7 and P21




Genotype
MGI:6414961
cn2
Allelic
Composition		 Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (44 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (992 available)
H3c2tm1Mak mutation (0 available); any H3c2 mutation (7 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased brain tumor incidence ( J:285841 )
• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
increased glioma incidence ( J:285841 )
• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin

nervous system
increased brain tumor incidence ( J:285841 )
• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
increased glioma incidence ( J:285841 )
• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
brain glioma DOID:0060108 J:285841




Genotype
MGI:6414964
cn3
Allelic
Composition		 Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (44 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (992 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased brain tumor incidence ( J:285841 )
• most mice succumb to spontaneous brain tumors
increased glioma incidence ( J:285841 )
• tumors are high-grade diffuse gliomas

nervous system
increased brain tumor incidence ( J:285841 )
• most mice succumb to spontaneous brain tumors
increased glioma incidence ( J:285841 )
• tumors are high-grade diffuse gliomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
brain glioma DOID:0060108 J:285841




Genotype
MGI:6414951
cn4
Allelic
Composition		 Acvr1tm1Mak/Acvr1+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (44 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:285841 )
• some mice fail to gain normal body weight and die before weaning

behavior/neurological
ataxia ( J:285841 )
• surviving mice show moderate ataxia

muscle
muscle spasm ( J:285841 )
• surviving mice show spasms when disrupted during rest

nervous system
abnormal brain development ( J:285841 )
• marker analysis indicates the differentiation of oligodendroglial lineage cells is blocked and neuroglial progenitors are upregulated
abnormal brainstem morphology ( J:285841 )
• higher density of PDGFRA+ cells in brainstems
abnormal glial cell physiology ( J:285841 )
• glial cells exhibit increased growth

neoplasm
neoplasm ( J:285841 )
N
• mice do not develop tumors




Genotype
MGI:6414958
cn5
Allelic
Composition		 Acvr1tm1Mak/Acvr1+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (44 available)
H3c2tm1Mak mutation (0 available); any H3c2 mutation (7 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:285841 )
• partial early postnatal lethality

neoplasm
neoplasm ( J:285841 )
N
• mice do not develop brain tumors




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory