Analysis Tools|
Allele Symbol Allele Name Allele ID |
H3c2tm1Mak targeted mutation 1, Tak W Mak MGI:6414914 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cells in primary brainstem glial cultures proliferate slightly faster than wild-type cells
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| N |
• mice are viable and appear to develop normally
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
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• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin
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• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
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• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| brain glioma | DOID:0060108 | J:285841 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• partial early postnatal lethality
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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