Phenotypes associated with this allele

• Allele Symbol: Scn11a^em3Akoi
• Allele Name: endonuclease-mediated mutation 3, Akio Koizumi
• Allele ID: MGI:6415027
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Scn11a^em3Akoi/Scn11a^+	involves: C57BL/6NCrSlc	MGI:6415036

Genotype
MGI:6415036

ht1

• Allelic Composition: Scn11a^em3Akoi/Scn11a⁺
• Genetic Background: involves: C57BL/6NCrSlc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system electrophysiology ( J:268091 )

• dorsal root ganglion neurons show increased resting membrane potentials

• input impedance of dorsal root ganglion neurons is higher in response to a current injection of 10 pA

abnormal action potential ( J:268091 )

• dorsal root ganglion neurons show increased firing frequency of the action potentials by high input-current stimulus

• however, other action potential parameters and current threshold do not differ in dorsal root ganglion neurons