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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flvcr2tm1.1Tda
targeted mutation 1.1, Thomas Arnold
MGI:6415546
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Flvcr2tm1.1Tda/Flvcr2tm1.1Tda
Tg(Tek-cre)5326Sato/0 		involves: C57BL/6J MGI:6415686
cn2
 		Flvcr2tm1.1Tda/Flvcr2tm1.1Tda
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: C57BL/6J MGI:6415689
cn3
 		Flvcr2tm1.1Tda/Flvcr2tm1.2Tda
Tg(Cdh5-cre/ERT2)1Rha/0 		involves: C57BL/6J MGI:6415692


Genotype
MGI:6415686
cn1
Allelic
Composition		 Flvcr2tm1.1Tda/Flvcr2tm1.1Tda
Tg(Tek-cre)5326Sato/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flvcr2tm1.1Tda mutation (0 available); any Flvcr2 mutation (25 available)
Tg(Tek-cre)5326Sato mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:287134 )
• as in null mice, no mice are present at weaning

cardiovascular system
abnormal vascular development ( J:287134 )
• as in null mice




Genotype
MGI:6415689
cn2
Allelic
Composition		 Flvcr2tm1.1Tda/Flvcr2tm1.1Tda
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flvcr2tm1.1Tda mutation (0 available); any Flvcr2 mutation (25 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:287134 )
N
• tamoxifen-treated mice exhibit normal blood brain barrier function
abnormal vascular endothelial cell morphology ( J:287134 )
• in response to supra-physiologic levels of VEGF, endothelial cells from tamoxifen-treated embryos exhibit reduced ability to adopt a tip cell phenotype compared with control cells

cellular
decreased endothelial cell proliferation ( J:287134 )
• in cells from tamoxifen-treated embryos in response to supra-physiologic levels of VEGF




Genotype
MGI:6415692
cn3
Allelic
Composition		 Flvcr2tm1.1Tda/Flvcr2tm1.2Tda
Tg(Cdh5-cre/ERT2)1Rha/0
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flvcr2tm1.1Tda mutation (0 available); any Flvcr2 mutation (25 available)
Flvcr2tm1.2Tda mutation (0 available); any Flvcr2 mutation (25 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:287134 )
N
• tamoxifen-treated mice exhibit normal blood brain barrier function




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory