Phenotypes associated with this allele

• Allele Symbol: Zc3h10^{tm1c(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1c, Wellcome Trust Sanger Institute
• Allele ID: MGI:6415552
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Ucp1-cre)1Evdr/0 Zc3h10^tm1c(EUCOMM)Wtsi/Zc3h10^tm1c(EUCOMM)Wtsi	involves: 129S4/SvJaeSor * C57BL/6N * FVB	MGI:6415592

Genotype
MGI:6415592

cn1

• Allelic Composition: Tg(Ucp1-cre)1Evdr/0; Zc3h10^{tm1c(EUCOMM)Wtsi}/Zc3h10^{tm1c(EUCOMM)Wtsi}
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6N * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased body fat mass ( J:287066 )

♂ • in males on a normal chow diet

abnormal brown adipose tissue thermogenesis ( J:287066 )

♂ • 30% decrease in oxygen consumption in brown adipose tissue from males

♂ • temperature of brown fat in cold exposed males is markedly decreased compared to wild-type controls

growth/size/body

increased body fat mass ( J:287066 )

♂ • in males on a normal chow diet

increased body weight ( J:287066 )

♂ • in males on a normal chow diet

homeostasis/metabolism

impaired adaptive thermogenesis ( J:287066 )

♂ • greater drop in body temperature in males after 3h of cold exposure compared to wild-type controls

decreased oxygen consumption ( J:287066 )

♂ • at all temperatures without changes in food consumption or physical activity in males

impaired glucose tolerance ( J:287066 )

♂ • higher glucose levels in a glucose tolerance test in males

insulin resistance ( J:287066 )

♂ • impaired insulin sensitivity in males during an insulin tolerance test