Phenotypes associated with this allele

• Allele Symbol: Cntnap4^em1Smoc
• Allele Name: endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• Allele ID: MGI:6415695
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cntnap4^em1Smoc/Cntnap4^em1Smoc	C57BL/6J-Cntnap4^em1Smoc	MGI:6415698

Genotype
MGI:6415698

hm1

• Allelic Composition: Cntnap4^em1Smoc/Cntnap4^em1Smoc
• Genetic Background: C57BL/6J-Cntnap4^em1Smoc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:287186 )

• latency to fall in the rotarod test are decreased

decreased locomotor activity ( J:287186 )

• total distance traveled and movement speed in the open field test are decreased

nervous system

abnormal substantia nigra pars compacta morphology ( J:287186 )

• TH+ cells in the substantia nigra pars compacta are decreased indicating nigral dopaminergic degeneration

• however, TH+ cell levels in the striatum are unchanged

neuron degeneration ( J:287186 )

• TH+ cells in the substantia nigra pars compacta are decreased indicating nigral dopaminergic degeneration

cellular

enhanced autophagy ( J:287186 )

• autophagy is induced in the substantia nigra pars compacta

homeostasis/metabolism

enhanced autophagy ( J:287186 )

• autophagy is induced in the substantia nigra pars compacta