Analysis Tools|
Allele Symbol Allele Name Allele ID |
Scn5aem1Coop endonuclease-mediated mutation 1, Thomas A Cooper MGI:6415727 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show similar ECG phenotypes that are seen on a FVB/NJ background
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| sick sinus syndrome | DOID:13884 |
OMIM:163800 OMIM:608567 |
J:279087 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• decrease in basal heart rate
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• mice exhibit sinus bradycardia at programmed electrical stimulation baseline
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• ventricular tachycardia is inducible in 1 of 5 mice
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• intracardiac pacing shows that mice are susceptible to various inducible arrhythmias
• mice show arrhythmias at programmed electrical stimulation baseline, including atrioventricular block in 3 of 5 mice, and afterdepolarizations in 3 of 5 mice that are either present simultaneously or separately
• 2 of 5 mice show premature atrial complexes at programmed electrical stimulation baseline
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• optical mapping shows delays in activation and propagation of conduction, prolonged action potential duration and decreased ventricular conduction velocity
• however, mice show no differences in ejection fraction, fractional shortening, or morphological differences, indicating that contractility is not affected
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• pacing in hearts shows atrioventricular block in 3 of 5 mice
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• intracardiac pacing indicates delays in sinoatrial node function, prolonged atrioventricular effective refractory period, and various inducible arrhythmias
• mice exhibit sinus bradycardia at programmed electrical stimulation baseline, with 4 of 5 mice showing either premature atrial complexes, sinus pause, or spontaneous reversion from bradycardia
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• variability in corrected QT interval
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• in vivo intracardiac pacing on anesthetized mutants shows delays in sinoatrial node function and prolonged atrioventricular effective refractory period
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|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• intracardiac pacing shows that mice are susceptible to inducible arrhythmias
|
|
• optical mapping shows delays in activation and propagation of conduction, a trend of prolonged action potential duration, and decreased ventricular conduction velocity
• however, mice show no differences in ejection fraction, fractional shortening, or morphological differences, indicating that contractility is not affected
|
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• pacing in hearts shows atrioventricular block
|
|
• variability in corrected QT interval
|
|
• in vivo intracardiac pacing on anesthetized mutants shows prolonged atrioventricular effective refractory period
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| sick sinus syndrome | DOID:13884 |
OMIM:163800 OMIM:608567 |
J:279087 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/09/2024 MGI 6.24 |
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