Phenotypes associated with this allele

• Allele Symbol: Ifnlr1^{tm1b(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:6416070
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ifnlr1^tm1b(EUCOMM)Wtsi/Ifnlr1^tm1b(EUCOMM)Wtsi	B6(Cg)-Ifnlr1^tm1b(EUCOMM)Wtsi	MGI:6710976

Genotype
MGI:6710976

hm1

• Allelic Composition: Ifnlr1^{tm1b(EUCOMM)Wtsi}/Ifnlr1^{tm1b(EUCOMM)Wtsi}
• Genetic Background: B6(Cg)-Ifnlr1^{tm1b(EUCOMM)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to viral infection ( J:287260 )

• mice infected with the CR6 strain of murine norovirus show higher CR6 shedding in the stool at day 7 postinfection (dpi) than wild-type mice, and have higher numbers of CR6 genome copies in the colon, indicating a failure to control persistent norovirus replication

increased susceptibility to Riboviria infection ( J:287260 )

• mice inoculated perorally with reovirus strain type 1 Lang (T1L) , show elevated levels of reovirus titers in the stool, indicating increased levels of virus shedding, and increased viral loads in jejunal and ileal tissues compared to wild-type mice

increased susceptibility to Orthomyxoviridae infection ( J:287260 )

• mice inoculated intranasally with mouse-adapted influenza A virus PR8 show more weight loss than wild-type mice and elevated levels of lung PR8 viral loads at 3 dpi, however they recover from weigh loss by day 14 as in wild-type mice