All Phenotypes Pithd1<tm1Ohi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pithd1^tm1Ohi
targeted mutation 1, Izumi Ohigashi
MGI:6416147

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pithd1^tm1Ohi/Pithd1^tm1Ohi	involves: C57BL/6N	MGI:6416161

Allelic Composition	Pithd1^tm1Ohi/Pithd1^tm1Ohi
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pithd1^tm1Ohi mutation (0 available); any Pithd1 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:285040 )

• females are fertile

• testis and epididymis weights are similar to controls

teratozoospermia ( J:285040 )

• significant reduction in the number of sperm with normal morphology and increase in the frequency of sperm with multiple heads

multi-headed sperm ( J:285040 )

• increase in the frequency of sperm with multiple heads

asthenozoospermia ( J:285040 )

• decrease in sperm velocity after 2h incubation

abnormal testis physiology ( J:285040 )

• decrease in proteasome activity in testicular cells

male infertility ( J:285040 )

• when mated to wild-type C57BL/6 females plug formation is observed but no pregnancies are detected

impaired fertilization ( J:285040 )

• in-vitro sperm fails to fertilize eggs under either the cumulus-intact or cumulus-free conditions but fertilization does take place under the zona pellucida condition

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:285040 )

• no abnormalities were detected in the function or development of cortical thymic epithelial cells

abnormal testis physiology ( J:285040 )

• decrease in proteasome activity in testicular cells

cellular

teratozoospermia ( J:285040 )

• significant reduction in the number of sperm with normal morphology and increase in the frequency of sperm with multiple heads

multi-headed sperm ( J:285040 )

• increase in the frequency of sperm with multiple heads

asthenozoospermia ( J:285040 )

• decrease in sperm velocity after 2h incubation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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