Phenotypes associated with this allele

• Allele Symbol: Muc4^tm1Unc
• Allele Name: targeted mutation 1, University of North Carolina
• Allele ID: MGI:6416171
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Muc4^tm1Unc/Muc4^tm1Unc	B6NTac.129(FVB)-Muc4^tm1Unc/Rand	MGI:6423102

Genotype
MGI:6423102

hm1

• Allelic Composition: Muc4^tm1Unc/Muc4^tm1Unc
• Genetic Background: B6NTac.129(FVB)-Muc4^tm1Unc/Rand

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:287566 )

♀ • female mice infected with SARS-CoV exhibit reduced body weight with some requiring euthanasia unlike control or male mice

respiratory system

respiratory distress ( J:287566 )

♀ • in female mice infected with SARS-CoV

growth/size/body

decreased body weight ( J:287566 )

♀ • female mice infected with SARS-CoV exhibit reduced body weight with some requiring euthanasia unlike control or male mice

immune system

increased susceptibility to Coronaviridae infection ( J:287566 )

♀ • female mice infected with the recombinant mouse adapted SARS-CoV (rMA15) exhibit reduced body weight with some requiring euthanasia, reduced histopathological damage, more rapid exhalation, and more labored breathing compared with control or male mice

♀ • however, mice exhibit normal viral load and male mice exhibit normal histopathological damage

increased susceptibility to Coronaviridae infection induced morbidity/mortality ( J:287566 )

♀ • female mice infected with SARS-CoV exhibit reduced body weight with some requiring euthanasia unlike control or male mice

increased susceptibility to Togaviridae infection ( J:287566 )

• mice infected with Chinkungunya virus exhibit augmented disease with early infection, displaying a biphasic swelling pattern more prominent in male mice compared with control mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Coronavirus infectious disease		DOID:0080599		J:287566